Authors: Dakhale GN, Chaudhari HV, Shrivastava M.
No study has ever examined the effect of vitamin C with metformin on fasting
(FBS) and postmeal blood glucose (PMBG) as well as glycosylated hemoglobin
(HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to
examine the effect of oral vitamin C with metformin on FBS, PMBG, HbA1c, and
plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients with type 2 DM
participated in a prospective, double-blind, placebo-controlled, 12-week study.
The patients with type 2 DM were divided randomly into placebo and vitamin C
group of 35 each. Both groups received the treatment for twelve weeks. Decreased
PAA levels were found in patients with type 2 diabetes mellitus. This level was
reversed significantly after treatment with vitamin C along with metformin
compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed
significant improvement after 12 weeks of treatment with vitamin C. In
conclusion, oral supplementation of vitamin C with metformin reverses ascorbic
acid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in
combination may be used in the treatment of type 2 DM to maintain good glycemic